Clinical research

DOI: 10.4244/EIJ-D-22-00836

Predictors of target lesion revascularisation after drug-eluting stent implantation for calcified nodules: an optical coherence tomography study

Tomoyo Hamana1, MD; Hiroyuki Kawamori1, MD, PhD; Takayoshi Toba1, MD, PhD; Shunsuke Kakizaki1, MD; Koichi Nakamura1, MD; Daichi Fujimoto1, MD, PhD; Satoru Sasaki1, MD; Hiroyuki Fujii1, MD; Yuto Osumi1, MD; Tomoo Fujioka1, MD; Makoto Nishimori1,2, MD, PhD; Amane Kozuki3, MD, PhD; Junya Shite3, MD, PhD; Masamichi Iwasaki4, MD; Tomofumi Takaya5, MD, PhD; Ken-ichi Hirata1, MD, PhD; Hiromasa Otake1, MD, PhD

Abstract

Background: Evidence of prognostic factors for stent failure after drug-eluting stent implantation for calcified nodules (CNs) is limited.

Aims: We aimed to clarify the prognostic risk factors associated with stent failure among patients who underwent drug-eluting stent implantation for CN lesions using optical coherence tomography (OCT).

Methods: This retrospective, multicentre, observational study included 108 consecutive patients with CNs who underwent OCT-guided percutaneous coronary intervention (PCI). To evaluate the quality of CNs, we measured their signal intensity and analysed the degree of signal attenuation. All CN lesions were divided into dark or bright CNs according to the half width of signal attenuation, greater or lower than 332, respectively.

Results: During the median follow-up period of 523 days, 25 patients (23.1%) experienced target lesion revascularisation (TLR). The 5-year cumulative incidence of TLR was 32.6%. Multivariable Cox regression analysis revealed that younger age, haemodialysis, eruptive CNs, dark CNs assessed by pre-PCI OCT, disrupted fibrous tissue protrusions, and irregular protrusions assessed by post-PCI OCT were independently associated with TLR. The prevalence of in-stent CNs (IS-CNs) observed at follow-up OCT was significantly higher...

Sign in to read
the full article

Forgot your password?
No account yet?
Sign up for free!

Create my pcr account

Join us for free and access thousands of articles from EuroIntervention, as well as presentations, videos, cases from PCRonline.com

Volume 19 Number 2
Jun 5, 2023
Volume 19 Number 2
View full issue


Key metrics

On the same subject

Clinical Research

10.4244/EIJ-D-21-00504 Mar 18, 2022
Prevalence, predictors, and outcomes of in-stent restenosis with calcified nodules
Tada T et al
free

CLINICAL RESEARCH

10.4244/EIJ-D-17-00962 Apr 6, 2018
A new optical coherence tomography-based calcium scoring system to predict stent underexpansion
Fujino A et al
free

Clinical research

10.4244/EIJ-D-21-00976 Oct 21, 2022
Prevalence and outcomes of stent thrombosis with in-stent calcified nodules: substudy from the REAL-ST registry
Takahashi Y et al
free

Clinical research

10.4244/EIJ-D-20-00539 Aug 27, 2021
Predictors and outcomes of neoatherosclerosis in patients with in-stent restenosis
Nakamura D et al
free

Debate

10.4244/EIJ-E-23-00002 Jun 5, 2023
All calcified nodules are made equal and require the same approach: pros and cons
Guagliumi G et al
free

10.4244/EIJV13I3A39 Jun 20, 2017
New light on second-generation drug-eluting stent restenosis
Gonzalo N et al
free

10.4244/EIJV16I5A65 Aug 28, 2020
OCT-derived coronary calcified nodules as a predictor of high-risk patients
Akasaka T and Kubo T
free
Trending articles
281.53

State-of-the-Art Review

10.4244/EIJ-D-21-00695 Nov 19, 2021
Transcatheter treatment for tricuspid valve disease
Praz F et al
free
243.2

State of the art

10.4244/EIJ-D-21-01117 Sep 20, 2022
Recanalisation of coronary chronic total occlusions
Di Mario C et al
free
208.35

State-of-the-Art Review

10.4244/EIJ-D-21-01034 Jun 3, 2022
Management of in-stent restenosis
Alfonso F et al
free
168.7

Translational research

10.4244/EIJ-D-21-00824 May 15, 2022
Bench test and in vivo evaluation of longitudinal stent deformation during proximal optimisation
Toth GG et al
free
167.05

Expert review

10.4244/EIJ-D-21-00690 May 15, 2022
Crush techniques for percutaneous coronary intervention of bifurcation lesions
Moroni F et al
free
151.03

State-of-the-Art

10.4244/EIJ-D-22-00776 Apr 3, 2023
Computed tomographic angiography in coronary artery disease
Serruys PW et al
free
118

Translational research

10.4244/EIJ-D-22-00718 Jun 5, 2023
Preclinical evaluation of the degradation kinetics of third-generation resorbable magnesium scaffolds
Seguchi M et al
110.35

Viewpoint

10.4244/EIJ-E-22-00007 May 15, 2022
TAVI at 20: how a crazy idea led to a clinical revolution
Eltchaninoff H et al
free
X

The Official Journal of EuroPCR and the European Association of Percutaneous Cardiovascular Interventions (EAPCI)

EuroPCR EAPCI
PCR ESC
Impact factor: 6.2
2022 Journal Citation Reports®
Science Edition (Clarivate Analytics, 2023)
Online ISSN 1969-6213 - Print ISSN 1774-024X
© 2005-2024 Europa Group - All rights reserved