In this issue of EuroIntervention, there are original research articles on: chest pain and coronary microvascular dysfunction in patients with angina and non-obstructive coronary arteries; coronary microvascular dysfunction from the Danish Study of Non-Invasive Diagnostic Testing in Coronary Artery Disease (Dan-NICAD); angiographic microcirculatory resistance after primary PCI; a preclinical study on the use of combined hepatic and renal artery denervation on blood pressure response and other cardiometabolic disorders. There is a research correspondence on acute coronary syndromes in the elderly; a flashlight explaining tip-in balloon grenadoplasty; and more.