This issue of EuroIntervention includes an ESC Clinical Consensus Statement on dual antiplatelet therapy for secondary prevention in patients with acute coronary syndrome; Original Research on door-to-unload time in STEMI patients with cardiogenic shock; the impact of direct left atrial pressure during M-TEER; and temporal trends in M-TEER for primary mitral regurgitation; a Flashlight on transcatheter papillary muscle banding; and moreThis EuroPCR issue of EuroIntervention opens with a State-of-the-Art on the timing of transcatheter aortic valve implantation; we continue with a Debate on prasugrel vs ticagrelor in acute coronary syndromes; our 5 Original Research articles cover glucocorticoids for post-TAVI pacemaker prevention; the 30-day results of the DOUBLE-CHOICE trial; optical coherence tomography vs angiography in true left main coronary artery bifurcation lesions; ticagrelor versus clopidogrel with concurrent direct oral anticoagulants in acute coronary syndromes; clinical benefit of renal denervation at 3 years; we also have news from PCR in this issue; and more...