In this issue of EuroIntervention, we bring you three Original Research articles presented at EuroPCR 2026: P2Y12 inhibitor monotherapy after complex PCI; ticagrelor monotherapy in STEMI; endotype-based treatment in ANOCA; followed by a Research Correspondence on the prevalence of vasomotor dysfunction after PCI; a Flashlight on a new-generation magnesium scaffold collapse; and more...