Caïa Crooijmans; Tijn Jansen; Behruz Yosofi; Fleur Adriaansen; Joan Meeder; Wouter Remkes; Marcel Beijk; Yolande Appelman; Tim van de Hoef; Annemiek de Vos; Valeria Paradies; Martijn Meuwissen; Nicola Vos; Els Olde Bijvank; Michael Magro; Stijn van den Oord; Karin Arkenbout; Ton Heestermans; Marlies Kok; Pier Woudstra; Melina den Haan; Patty Winkler; Arnoud van ‘t Hof; Hester den Ruijter; Aysun Cetinyurek-Yavuz; Niels van Royen; Suzette Elias-Smale; Aukelien Dimitriu-Leen; Peter Damman; on behalf of the NL-CFT investigators

doi:10.4244/EIJ-D-25-01215

Prevalence of vasomotor dysfunction in patients with residual or recurrent angina after percutaneous coronary intervention

Caïa Crooijmans¹, MD; Tijn P.J. Jansen¹^,², MD, PhD; Behruz Yosofi¹, MD; Fleur W. Adriaansen¹, MD; Joan G. Meeder², MD, PhD; Wouter S. Remkes², MD; Marcel A.M. Beijk³, MD, PhD; Yolande Appelman³, MD, PhD; Tim P. van de Hoef⁴, MD, PhD; Annemiek de Vos⁵, MD; Valeria Paradies⁶, MD, PhD; Martijn Meuwissen⁷, MD, PhD; Nicola S. Vos⁸, MD, PhD; Els G.M. Olde Bijvank⁹, MD; Michael Magro¹⁰, MD, PhD; Stijn C.H. van den Oord¹¹, MD, PhD; Karin E. Arkenbout¹², MD, PhD; Ton A.A.C.M. Heestermans¹³, MD, PhD; Marlies M. Kok¹⁴, MD, PhD; Pier Woudstra¹⁵, MD, PhD; Melina C. den Haan¹⁶, MD, PhD; Patty Winkler¹⁷, MD, PhD; Arnoud van ‘t Hof¹⁸, MD, PhD; Hester M. den Ruijter¹⁹, PhD; Aysun Cetinyurek-Yavuz²⁰, PhD; Niels van Royen¹, MD, PhD; Suzette Elias-Smale¹, MD, PhD; Aukelien C. Dimitriu-Leen¹, MD, PhD; Peter Damman¹, MD, PhD; on behalf of the NL-CFT investigators

Residual or recurrent angina after treating obstructive coronary artery disease (CAD) with percutaneous coronary intervention (PCI) occurs in up to half of patients. Mechanisms include residual stenoses, a suboptimal stent result, or coronary vasomotor dysfunction (CVDys).1 Patients with persistent symptoms frequently undergo repeated diagnostic testing. Previous research predominantly focused on the physiology of obstructive CAD and optimal revascularisation. Few data are available on the role of CVDys in these patients.

The current chronic coronary syndromes guideline recommends coronary function testing (CFT) for the identification of coronary vasomotor dysfunction in patients who have angina with no obstructive coronary artery disease (ANOCA).2 CFT has proven to be safe, and stratified medical therapy leads to sustained relief of symptoms and improved quality of life.34 However, in the management of patients with residual angina after the treatment of obstructive coronary artery disease, CFT is not mentioned. We hypothesised that CVDys is common in these patients. Therefore, we aimed to characterise patients undergoing CFT for anginal complaints after previous PCI and compare them to ANOCA patients without previous PCI.

Data from the previously...

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