This EuroPCR issue of EuroIntervention opens with a State-of-the-Art on the timing of transcatheter aortic valve implantation; we continue with a Debate on prasugrel vs ticagrelor in acute coronary syndromes; our 5 Original Research articles cover glucocorticoids for post-TAVI pacemaker prevention; the 30-day results of the DOUBLE-CHOICE trial; optical coherence tomography vs angiography in true left main coronary artery bifurcation lesions; ticagrelor versus clopidogrel with concurrent direct oral anticoagulants in acute coronary syndromes; clinical benefit of renal denervation at 3 years; we also have news from PCR in this issue; and more...