This issue of EuroIntervention has a State-of-the-Art reviewing antithrombotic therapy in complex PCI with a look at different types, duration, and management of antithrombotic strategies. In original research: an article on optimal minimal stent areas after left main crossover stenting; Valve Academic Research Consortium High Bleeding Risk (VARC-HBR) criteria for risk stratification and prediction of bleeding risk in TAVI patients. There is a translational research bench study on the balloon-expandable DurAVR valve for TAVI, ViV TAVI and redo-TAVI; a research correspondence on redo-TAVI with the supra-annular self-expanding THV for short-frame transcatheter heart valves; a viewpoint on early dual antiplatelet therapy interruption; and more...