Coronary flow capacity: where to next?

EuroIntervention 2021;17:e269-e270. DOI: 10.4244/EIJV17I4A47

Nils Johnson
Nils P. Johnson1, MD, MS; K. Lance Gould1, MD
1. Weatherhead PET Center, Division of Cardiology, Department of Medicine, McGovern Medical School at UTHealth and Memorial Hermann Hospital, Houston, TX, USA
The novel results presented in this issue of EuroIntervention from an international collaboration on intracoronary physiologic assessment1 provide a timely opportunity to critically assess the concept of coronary flow capacity (CFC) that we introduced in 20122.

Why coronary flow capacity?

Due to autoregulation under baseline conditions that maintains myocardial blood flow over a wide range of coronary pressures (and hence tolerates a surprising burden of epicardial atherosclerosis), only stress measurements allow a causal link with symptoms or outcomes in stable patients. Yet two separate conceptual metrics exist as candidates: hyperaemic flow (or perfusion, if adjusted for supplied myocardial mass) ...

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