The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Editorial

Ischaemic risk stratification after deferral of revascularisation on the basis of fractional flow reserve

EuroIntervention 2021;16:1131-1133. DOI: 10.4244/EIJV16I14A204

1. Hospital General ISSSTE Querétaro - Autonomous University of Querétaro, Santiago de Querétaro, México; 2. Department of Cardiology, Amsterdam UMC, Amsterdam, the Netherlands


In a seminal experimental work almost 50 years ago, Gould and Lipscomb described the haemodynamic consequences of progressive focal reductions in coronary artery diameter on coronary flow1. It was observed that stenosis ≥50% and ≥85% of the lumen diameter impairs maximal hyperaemic and baseline flow, respectively. A sine qua non relationship between coronary stenosis, myocardial ischaemia and adverse cardiovascular events matured, and slowly became the reigning paradigm of ischaemic heart disease (IHD). In contrast with this “stenosis-centred” theory of IHD, Likoff et al described a group of women with angina, ischaemic electrocardiographic responses to physical exercise, and normal ...

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