The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)


Coronary flow reserve and coronary flow capacity at a time of shifting paradigms of ischaemic heart disease

EuroIntervention 2021;16:e1463-e1465. DOI: 10.4244/EIJV16I18A264

1. Hospital Clinico San Carlos IDISSC, Universidad Complutense de Madrid, Madrid, Spain; 2. Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan

“As is our confidence, so is our capacity” – William Hazlitt

Coronary flow reserve (CFR) was originally formulated as a functional index to explore the functional relevance of coronary stenoses1. In a communicative way, the rationale behind CFR could be expressed as follows: “If you want to know if a stenosis is severe, go and ask the microcirculation”. A clever approach - coronary stenosis first causes subtended arterioles to vasodilate to maintain resting flow and, eventually, also causes a decrease in maximal hyperaemic flow. All this trims the range of microvascular vasodilation, indirectly ...

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