The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)


Coronary physiological parameters at a crossroads

EuroIntervention 2017;13:e145-e148 published online e-edition June 2017. DOI: 10.4244/EIJV13I2A20

1. International Centre for Circulatory Heath, Imperial College London, London, United Kingdom; 2. Academic Medical Center, Amsterdam, the Netherlands

Coronary angiography remains the gold standard in the diagnosis of coronary artery disease in the cardiac catheterisation laboratory. However, the limitations of angiography for assessing epicardial stenosis severity led, in the 1990s, to the introduction of sensor-equipped guidewires that measure coronary pressure and flow selectively distal to a lesion1. The most frequently used parameter is fractional flow reserve (FFR), defined as the ratio of the pressure distal to a lesion relative to the aortic pressure that assumes minimal influence of the microvascular resistance during hyperaemic conditions2. An alternative is the assessment of coronary flow reserve (CFR), defined as the ...

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