The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)


Stratifying cardiovascular risk in patients with microvascular dysfunction: new insights from emerging physiology metrics

EuroIntervention 2021;17:532-533. DOI: 10.4244/EIJV17I7A95

1. Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom; 2. Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University London, London, United Kingdom; 3. Institute of Cardiovascular Sciences, University College London, London, United Kingdom
Coronary microvascular dysfunction (CMD) has been increasingly recognised as a common cause of myocardial ischaemia and typical angina symptoms. Recent reports have examined the mechanisms that are responsible for the mismatch of demand-supply of coronary blood flow in patients with CMD, providing unique insights about the pathophysiological processes that are responsible for this disease1,2. Today, two different endotypes of CMD have been identified, the structural endotype that is associated with increased nitric oxide synthase (NOS) activity resulting in augmented coronary flow at baseline, and the functional endotype where there is a weak augmentation of coronary blood flow at stress due ...

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