Interventions for valvular disease and heart failure

Transcatheter mitral valve replacement (TMVR): annular or apical fixation?

EuroIntervention 2020;16:510-517. DOI: 10.4244/EIJ-D-19-00614

Georg Lutter
Georg Lutter1,2, MD, PhD; Huangdong Dai1,3, MD; Jan Hinnerk Hansen4, MD; Derk Frank5, DM; Assad Haneya2, MD; Dan Simionescu6, PhD; Jochen Cremer2, MD; Thomas Puehler1,2, MD
1. Department of Experimental Cardiac Surgery and Heart Valve Replacement, University Hospital Schleswig-Holstein, Campus Kiel, Germany; 2. Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Germany; 3. Department of Cardiac Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China; 4. Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein, Campus Kiel, Germany; 5. Department of Cardiology and Angiology, University Hospital Schleswig-Holstein, Campus Kiel, Germany; 6. Department of Bioengineering, Clemson University, Clemson SC, USA

Aims: The aim of this study was to evaluate the impact of two different transcatheter mitral valve replacement (TMVR) fixation strategies on the neo left ventricular outflow tract (neo-LVOT) and aorto-mitral angulation (AMA) after TMVR.

Methods and results: Two different self-expanding nitinol valved stents were developed for transapical TMVR. In one group, the stents were fixed with an annular fixation system (ANN group, n=6). These prototypes were compared with an apical tether fixation TMVR system (AP group, n=11) in another group. Echocardiographic evaluation of the AMA and the neo-LVOT was conducted before and one hour after implantation. Maximal and minimal AMA (AMAmax and AMAmin) during the cardiac cycle of the AP group were significantly narrower than those of the ANN group (AMAmax: 39±8° vs 67±15°, p<0.001, AMAmin: 33±10° vs 56±22°, p=0.009). More severe reduction of the neo-LVOT diameter was observed in the ANN group (60±11% vs 26±14%, p<0.001). The ANN group had a higher peak velocity through the neo-LVOT post implantation (200±52 cm/s vs 108±15 cm/s, p<0.001).

Conclusions: The apical fixation system maintains a smaller and more stable aorto-mitral angulation and a larger neo-LVOT, thereby reducing the risk of postoperative neo-LVOT obstruction in this experimental setting.

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othermitral valve diseasetavitransapical
Interventions for valvular diseaseMitral valve replacement and repair
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