Interventions for hypertension and stroke

Transcatheter closure of atrial septal defect and patent foramen ovale with Carag bioresorbable septal occluder: first-in-man experience with 24-month follow-up

EuroIntervention 2022;17:1536-1537. DOI: 10.4244/EIJ-D-21-00740

Kolja Sievert
Kolja Sievert1, MD; Stefan Bertog1, MD; Björn Söderberg2, MD; Sameer Gafoor1, MD; Ilona Hofmann1, MD; Iris Grunwald1,3, MD; Nalan Schnelle1,4, MD; Horst Sievert1, MD
1. CardioVascular Center Frankfurt CVC, Frankfurt, Germany; 2. Department of Pediatrics at Institute of Clinical Sciences, Gothenburg University, Gothenburg, Sweden; 3. University of Dundee, Dundee, United Kingdom; 4. Klinikum Kassel, Kassel, Germany
Introduction The Carag bioresorbable septal occluder (CBSO; CARAG AG, Baar, Switzerland) is the first interatrial septal occluder with bioresorbable framework.

Methods STUDY DESIGN The study was a single-centre, prospective, single-arm trial. Ethics committee/regulatory approvals were obtained. NCT01960491.

DEVICE DESCRIPTION The CBSO is the first occluder where the metal framework has been replaced with bioresorbable poly(lactic-co-glycolic) acid (PLGA) (Figure 1). The CBSO is self-centering, with two opposing polyester covers attached to a PLGA monofilament framework. The non-bioresorbable polyester fabric is secured to the monofilaments by platinum–iridium markers/sutures. A distal tip made of Phynox ...

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