The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Clinical research

The effect of repeated ischaemic periods on left ventricular dynamics during percutaneous coronary intervention

EuroIntervention 2010;6:623-629 published online ahead of print February 2010.

Department of Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands


Aims: To study online left ventricular (LV) dynamic effects of transmural ischaemia and reperfusion during consecutive balloon coronary occlusions in the setting of percutaneous coronary intervention (PCI).

Methods and results: In 10 consecutive unselected patients with stable angina (seven males, mean age 62±3 years) who underwent elective PCI, LV dynamics were continuously recorded using a pressure-conductance catheter to simultaneously measure pressure and volume (PV-loop). The effects of a prolonged balloon coronary occlusion (148±19 s) and a second occlusion on various LV function parameters were studied, as well as recovery of these parameters after reperfusion. Ischaemia caused an immediate (&...

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