Sirolimus-eluting or everolimus-eluting stents for coronary artery disease: 5-year outcomes of the randomised BIOFLOW-IV trial

EuroIntervention 2023;18. DOI: 10.4244/EIJ-D-22-00526

Ton Slagboom
Ton Slagboom1, MD; Ralph Toelg2, MD; Bernhard Witzenbichler3, MD; Michael Haude4, MD; Monica Masotti5, MD; Rafael Ruiz Salmeron6, MD; Adam Ryszard Witkowski7, MD; Masaaki Uematus8, MD; Akihiko Takahashi9, MD; Ron Waksman10, MD; Shigeru Saito11, MD
1. Cardiology Unit, OLVG, Amsterdam, the Netherlands; 2. Herzzentrum, Segeberger Kliniken, Bad Segeberg, Germany; 3. Department of Cardiology and Pneumology, Helios Amper-Klinikum, Dachau, Germany; 4. Lukaskrankenhaus Medizinische Klinik I, Städtische Kliniken Neuss, Neuss, Germany; 5. Department of Cardiology, Hospital Clínic de Barcelona, Barcelona, Spain; 6. Haemodynamic Unit, Hospital Universitario Virgen Macarena, Seville, Spain; 7. National Institute of Cardiology, Warsaw, Poland; 8. Kansai Rosai Hospital Cardiovascular Center, Amagasaki, Japan; 9. Sakurakai Takahashi Hospital, Kobe, Japan; 10. MedStar Health Research Institute, Washington, DC, USA; 11. Okinawa Tokushukai Shonan Kamakura General Hospital, Kamakura, Japan
Corrigendum Figures 1A and 1C of this article have been replaced in the online version. DP-SES has been replaced with DP-EES. 17th January 2022. Introduction A large body of evidence is available for biodegradable polymer stents1, but long-term data are scarce and predominantly evaluated for Caucasian subjects. The BIOFLOW-IV trial aimed to provide additional data, comparing the safety and effectiveness of the ultrathin Orsiro biodegradable polymer sirolimus-eluting stent (BP-SES; Biotronik) with the XIENCE Prime/XIENCE Xpedition durable polymer everolimus-eluting stent (DP-EES; Abbott). We herein report final 5-year data.

Methods The BIOFLOW-IV study has been described previously2, and is registered at ...

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