The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)


Lost in translational filters between peers

EuroIntervention 2017;13:e1384-e1385 published online e-edition December 2017. DOI: 10.4244/EIJ-D-17-00904

1. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA; 2. Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 3. CBSET, Lexington, MA, USA

In a recent issue of EuroIntervention, two articles1,2 and an editorial3 detailed the translational journey taken by Qvanteq’s ultra-hydrophilic stent platform. Bench-top studies and animal experiments in two species of swine as well as rabbits suggested that a reduction in restenosis and stent thrombosis might be anticipated based on preclinical indices. In contrast, the first-in-man (FIM) study did not corroborate these results. Ultra-hydrophilic devices had a rate of neointimal formation similar to that found in contemporary bare metal stents (BMS). Rightfully, these reports question the relevance of preclinical models when ultimate risk/benefit plays out in humans with ...

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