The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Impact of target lesion location on procedural and angiographic outcomes of rotational atherectomy versus modified balloon angioplasty prior to drug-eluting stent implantation in severely calcified coronary lesions:a subgroup analysis of the PREPARE-CALC randomized trial

DOI: 10.4244/EIJ-D-19-00488

1. Deutsches Herzzentrum, Munich, Germany, Germany
2. Heart Center, Segeberger Kliniken, Bad Segeberg, Germany
3. Deutsches Herzzentrum, Munich, Germany
4. Heart Center, Segeberger Kliniken, Bad Segeberg, Germany
5. Deutsches Herzzentrum, Munich, Germany
6. Heart Center Leipzig at the University of Leipzig, Germany
7. Deutsches Herzzentrum, Munich, Germany
8. Deutsches Herzzentrum, Munich, Germany
9. Heart Center, Segeberger Kliniken, Bad Segeberg, Germany
10. Deutsches Herzzentrum, Munich, Germany. DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance
11. Heart Center Leipzig at the University of Leipzig, Germany

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Percutaneous coronary intervention (PCI) of calcified coronary lesions remains a challenge in routine clinical practice. Optimal lesion preparation prior to stent implantation is essential in this lesion subset [1]. The randomized PREPARE-CALC (The Comparison of Strategies to PREPARE Severely CALCified Coronary Lesions) trial demonstrated superiority for a strategy of lesion preparation with rotational atherectomy (RA) prior to drug-eluting stent (DES) implantation compared to a modified balloon (MB) angioplasty strategy [2]. As lesion location may have an important influence on device deliverability and strategy success, the Aims:of this subanalysis was to investigate the interaction between treatment effect and lesion location.

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