The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Coronary interventions

Outcomes of rotational atherectomy versus modified balloon angioplasty in severely calcified coronary lesions based on target lesion location: a post hoc analysis of the PREPARE-CALC randomised trial

EuroIntervention 2020;16:e322-e324. DOI: 10.4244/EIJ-D-19-00488

1. Deutsches Herzzentrum, Munich, Germany; 2. Heart Center, Segeberger Kliniken, Bad Segeberg, Germany; 3. Dublin Cardiovascular Research Institute, Mater Private Hospital, Dublin, Ireland; 4. School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland; 5. Heart Center Leipzig at the University of Leipzig, Leipzig, Germany; 6. DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
Introduction

Percutaneous coronary intervention (PCI) of calcified coronary lesions remains a challenge in routine clinical practice. Optimal lesion preparation prior to stent implantation is essential in this lesion subset1. The randomised PREPARE-CALC (The Comparison of Strategies to PREPARE Severely CALCified Coronary Lesions) trial demonstrated superiority for a strategy of lesion preparation with rotational atherectomy (RA) prior to drug-eluting stent (DES) implantation compared to a modified balloon (MB) angioplasty strategy2. As lesion location may have an important influence on device deliverability and strategy success, the aim of this sub-analysis was to investigate the interaction between treatment effect and lesion location.##...

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