Experimental research

Endothelial function rather than endothelial restoration is altered in paclitaxel- as compared to bare metal-, sirolimus and tacrolimus-eluting stents

EuroIntervention 2010;6:117-125.

Heleen van Beusekom
Heleen M.M. van Beusekom1*, PhD; Oana Sorop1, PhD; Mieke van den Heuvel1,2, MD, MSc; Yoshinobu Onuma1, MD; Dirk J. Duncker1, MD, PhD; A.H. Jan Danser2, PhD; Willem J. van der Giessen1,3, MD, PhD
1. Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands; 2. Division of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands; 3. Interuniversity Cardiology Institute of the Neth

Aims: Drug eluting stents (DES) are under scrutiny for late stent thrombosis. Impaired re-endothelialisation is proposed as an explanation but coronary and peripheral-artery models disagree

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tacrolimus-sirolimus-paclitaxel-drug-eluting stentsdelayed healingneointimastent thrombosisendotheliummicrocirculationnitric oxide
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