Image – Interventional flashlight

DOI: 10.4244/EIJ-D-18-01212

Balloon pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension

Lorenz Räber1, MD; Yasushi Ueki1, MD; Irene M. Lang2, MD

Figure 1. Imaging of left A10 before and after balloon angioplasty. Panels A-C illustrate angiograms. Panels D and E show OCT images in the planes highlighted in panels A and C.

A 65-year-old dyspnoeic male was diagnosed with chronic thromboembolic pulmonary hypertension (CTEPH) and a mean pulmonary arterial pressure of 45 mmHg, cardiac index of 2.4 L/min/m2, and pulmonary vascular resistance of 560 dyn·s·cm–5. The interdisciplinary PH board classified the patient’s CTEPH as technically operable with a poor risk-benefit ratio. An alternative mechanical treatment is balloon pulmonary angioplasty (BPA), a recently refined percutaneous technique that is emerging in Europe1. Figure 1A shows direct injection of left A10 during the patient`s first BPA session, depicting a focal bifurcational lesion. Optical coherence tomography showed a typical chanelled organised thrombus (Figure 1D, Moving image 1). After a single 8 atm inflation of a 4/20 mm MAVERICK™ balloon (Boston Scientific, Marlborough, MA, USA) (Figure 1B), angiography demonstrated adequate expansion of the lesion (Figure 1C). OCT immediately after balloon angioplasty (Figure 1E, Moving image 2) documented eccentric compression of obstructive material, without medial dissection (Figure 1D, arrows flanking the OCT catheter point to the structures displaced between Figure 1D and Figure 1E). “Breaking webs without dissection of the media” is the principle of BPA, and distinguishes this technique from coronary balloon angioplasty. Sparing the media is an interventional goal that is not always met, but may be achieved by using undersized balloons2. The fact that CTEPH is a disease of the lumen rather than a disease of the vessel wall itself may be a further reason for the lack of restenosis after BPA. This case illustrates the mechanical concept of BPA breaking and displacing intravascular webs, thus restoring normal flow and vessel function.

Conflict of interest statement

The authors have no conflicts of interest to declare.

Supplementary data

To read the full content of this article, please download the PDF.

Moving image 1. OCT before balloon angioplasty showing organised thrombus and lesional negative vascular remodelling.

Moving image 2. OCT immediately after balloon angioplasty illustrates compression of obstructive material without medial dissection.

Volume 15 Number 9
Oct 4, 2019
Volume 15 Number 9
View full issue


Key metrics

Suggested by Cory

10.4244/EIJV12SXA8 May 16, 2016
Percutaneous treatment of chronic thromboembolic pulmonary hypertension (CTEPH)
Muller DW and Liebetrau C
free
Trending articles
151.43

State-of-the-Art

10.4244/EIJ-D-22-00776 Apr 3, 2023
Computed tomographic angiography in coronary artery disease
Serruys PW et al
free
55.9

Clinical research

10.4244/EIJ-D-22-00621 Feb 20, 2023
Long-term changes in coronary physiology after aortic valve replacement
Sabbah M et al
free
54.9

Expert review

10.4244/EIJ-D-21-01010 Jun 24, 2022
Device-related thrombus following left atrial appendage occlusion
Simard T et al
free
43.75

Clinical Research

10.4244/EIJ-D-21-01091 Aug 5, 2022
Lifetime management of patients with symptomatic severe aortic stenosis: a computed tomography simulation study
Medranda G et al
free
39.95

Clinical research

10.4244/EIJ-D-22-00558 Feb 6, 2023
Permanent pacemaker implantation and left bundle branch block with self-expanding valves – a SCOPE 2 subanalysis
Pellegrini C et al
free
X

The Official Journal of EuroPCR and the European Association of Percutaneous Cardiovascular Interventions (EAPCI)

EuroPCR EAPCI
PCR ESC
Impact factor: 7.6
2023 Journal Citation Reports®
Science Edition (Clarivate Analytics, 2024)
Online ISSN 1969-6213 - Print ISSN 1774-024X
© 2005-2024 Europa Group - All rights reserved