The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Reply to the letter to the editor

Reply to the Letter to the Editor “Is it time to abandon drug-eluting stents for saphenous venous graft percutaneous coronary intervention?”

EuroIntervention 2019;15:211-212. DOI: 10.4244/EIJ-D-18-00666R

1. Department of Medicine, University of Florida, Gainesville, FL, USA; 2. Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, MN, USA; 3. North Florida/South Georgia Veterans Health System, Gainesville, FL, USA
We appreciate the interest of Sethi et al1 in our meta-analysis2. Sethi et al argue that there are several issues with the meta-analysis that could lead to the misinterpretation of the findings. First, they suggest that the sensitivity analysis excluding DELAYED RRISC3 showed a possible benefit with drug-eluting stents (DES). While this analysis might be statistically significant, there needs to be a scientific rationale for how a sensitivity analysis is conducted. The usual scenario is to exclude the largest trial and determine if the overall interpretation remains the same. In this case the exclusion of the smallest trial found a ...

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