DOI:

MitraClip repair for severe mitral regurgitation: initial Asian experience

Yeo K.K.1, Tay E.2, Ding Z.P.1, Yip J.2, Chua Y.L.1, Lim S.T.1, Raymond W.2, Kenny S.1, Kong W.2, Tan J.1, Chai P.2, Ting P.1, Hon J.2, Ewe S.H.1, Ling L.H.2, Yeo T.C.2, Tan H.C.2, Koh T.H.1

Treatment and consequences of regurgitation during transcatheter valve therapies

MitraClip repair for severe mitral regurgitation: initial Asian experience

Aims: Percutaneous mitral valve repair for severe mitral regurgitation (MR) is now possible utilising the MitraClip valve repair system. The aim of this study is to describe the initial experience in Asia with the MitraClip device.

Methods and results: Twenty-eight patients underwent treatment with the MitraClip between April 2011 and April 2012 in two tertiary academic medical centres in Singapore. Data on demographic, clinical and procedural characteristics, as well as outcomes were collected prospectively in a registry and analysed. Of the 28, 14 (50%) had functional MR, 12 (42.9%) had degenerative MR and two (7.1%) had mixed pathology. The median age was 66 years, 13 (46.4%) were male, and 22 (78.6%) were Chinese. The mean BMI was 23.7, seven (25%) were in NYHA Class II and 21 (75%) were in NYHA Class III-IV. Ten (35.7%) had diabetes mellitus and eight (28.6%) had prior coronary bypass surgery. The median LVEF was 40% and the median logistic EuroSCORE II was 2.8. Seventeen (60.7%) patients had one clip while 10 (35.7%) had two clips. Acute procedural success was achieved in 26 patients (92.9%). Of the two patients who were technically procedural failures, one was a clinical success. In this patient, with severe MR from Barlow’s disease, prior breast cancer with radiation therapy, cardiac cirrhosis, chronic renal failure and a body weight of 37 kg, the goal of therapy was to reduce MR from 4+ to 3+. This was achieved and the patient had dramatic clinical improvement. Of the two major adverse events, one was from single leaflet attachment, urgent surgery and eventual death in a patient with functional MR; and the other was from oesophageal laceration from the transoesophageal echo probe resulting in blood transfusions.

Conclusions: The MitraClip has been successfully used in North America and Europe for the percutaneous treatment of severe MR. This case series demonstrates that percutaneous mitral valve repair using the MitraClip can be safely and successfully performed in an Asian population for both degenerative and functional MR.

Volume 8 Supplement Q
Sep 30, 2012
Volume 8 Supplement Q
View full issue


Key metrics

Suggested by Cory

10.4244/EIJV9I5A102 Sep 27, 2013
MitraClip® via direct right atrial access in case of a missing inferior vena cava
Frerker C et al
free

10.4244/EIJV11SWA11 Sep 17, 2015
The MitraClip transcatheter mitral valve repair system
Grasso C and Baldus S
free

MITRAL VALVE INTERVENTIONS

10.4244/EIJV12SYA14 Sep 18, 2016
The MitraClip system: strategies for optimal patient selection and optimised results
Grasso C and Ince H
free

10.4244/EIJV7I12A230 Apr 20, 2012
Tools and Techniques: Edge-to-edge percutaneous MitraClip® implantation
Alegria-Barrero E et al
free
Trending articles
151.43

State-of-the-Art

10.4244/EIJ-D-22-00776 Apr 3, 2023
Computed tomographic angiography in coronary artery disease
Serruys PW et al
free
55.9

Clinical research

10.4244/EIJ-D-22-00621 Feb 20, 2023
Long-term changes in coronary physiology after aortic valve replacement
Sabbah M et al
free
54.9

Expert review

10.4244/EIJ-D-21-01010 Jun 24, 2022
Device-related thrombus following left atrial appendage occlusion
Simard T et al
free
43.75

Clinical Research

10.4244/EIJ-D-21-01091 Aug 5, 2022
Lifetime management of patients with symptomatic severe aortic stenosis: a computed tomography simulation study
Medranda G et al
free
39.95

Clinical research

10.4244/EIJ-D-22-00558 Feb 6, 2023
Permanent pacemaker implantation and left bundle branch block with self-expanding valves – a SCOPE 2 subanalysis
Pellegrini C et al
free
X

The Official Journal of EuroPCR and the European Association of Percutaneous Cardiovascular Interventions (EAPCI)

EuroPCR EAPCI
PCR ESC
Impact factor: 7.6
2023 Journal Citation Reports®
Science Edition (Clarivate Analytics, 2024)
Online ISSN 1969-6213 - Print ISSN 1774-024X
© 2005-2024 Europa Group - All rights reserved