Rebecca Torguson1, MPH; Gary S. Mintz2, MD; Cheng Zhang2, PhD; Brian C. Case2, MD; Carlo Di Mario3, MD; Hector M. Garcia-Garcia2, MD, PhD; Ron Waksman2, MD
1. The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 2. Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA; 3. Structural Interventional Cardiology, University Hospital Careggi, Florence, Italy
Anecdotal series have suggested little correlation between the lipid content of the coronary arteries, the maximal Lipid Core Burden Index within any 4 mm segment (maxLCBI4mm) as measured by near infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) or its change over time, and the serum-measured low-density lipoprotein cholesterol (LDL-C), but they have shown modest association with high-density lipoprotein cholesterol (HDL-C)12. Whether these relationships hold in a larger data set remains unknown. The Lipid Rich Plaque (LRP) study (ClinicalTrials.gov: NCT02033694) showed that lipid-rich plaques (maxLCBI4mm >400) were associated with a greater incidence of non-culprit major adverse cardiovascular events3. The current subanalysis ...