Coronary interventions

Lipid-rich plaque density and low-density lipoprotein cholesterol in statin-treated versus statin-naïve patients: a post hoc analysis of the LRP study

EuroIntervention 2022;18:91-93. DOI: 10.4244/EIJ-D-21-00701

Rebecca Torguson
Rebecca Torguson1, MPH; Gary S. Mintz2, MD; Cheng Zhang2, PhD; Brian C. Case2, MD; Carlo Di Mario3, MD; Hector M. Garcia-Garcia2, MD, PhD; Ron Waksman2, MD
1. The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 2. Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA; 3. Structural Interventional Cardiology, University Hospital Careggi, Florence, Italy
Introduction Anecdotal series have suggested little correlation between the lipid content of the coronary arteries, the maximal Lipid Core Burden Index within any 4 mm segment (maxLCBI4mm) as measured by near infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) or its change over time, and the serum-measured low-density lipoprotein cholesterol (LDL-C), but they have shown modest association with high-density lipoprotein cholesterol (HDL-C)12. Whether these relationships hold in a larger data set remains unknown. The Lipid Rich Plaque (LRP) study ( NCT02033694) showed that lipid-rich plaques (maxLCBI4mm >400) were associated with a greater incidence of non-culprit major adverse cardiovascular events3. The current subanalysis ...

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