The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

First-in-human results of the OMEGA™ Left Atrial Appendage Occluder for Patients with Non-Valvular Atrial Fibrillation

DOI: 10.4244/EIJ-D-20-00552

1. Department of Cardiology, Dunedin Hospital, New Zealand, New Zealand
2. Cardiac Center and Division of Cardiovascular Disease, Department of Medicine, King Chulalongkorn Memorial Hospital and Chulalongkorn University, Bangkok, Thailand
3. The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Denmark
4. Cardiac Center and Department of Radiology, King Chulalongkorn Memorial Hospital and Chulalongkorn University, Bangkok, Thailand

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Several strategies have been devised to obliterate the left atrial appendage (LAA) space, which is the suspected origin of the majority of cardioembolic thrombi in patients with non-valvular atrial fibrillation (NVAF) - related stroke (1). The OMEGA™ LAA occluder is a novel self-expandable, cup-and-disc device made from a continuous, platinum-coated nitinol wire mesh (Figure 1), designed to occlude the LAA. The cup and disc are linked together by a flexible connecting waist. The disc has a polypropylene fabric securely sewn inside it, adding to the occlusive aspect of the device. For stabilization, the cup carries 6 to 10 anchoring hooks. This study reports on the first-in-human experience and procedural safety and efficacy of the OMEGA™ LAA occluder.

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