The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Comparison of Acute Thrombogenicity and Albumin Adsorption in Three Different Durable Polymer Coronary Drug-Eluting Stents

DOI: 10.4244/EIJ-D-19-00938

1. CVPath Institute, Gaithersburg, MD, United States, United States
2. Abbott Vascular, Santa Clara, CA, United States
Disclaimer:

As a public service to our readership, this article - peer reviewed by the Editors of EuroIntervention - has been published immediately upon acceptance as it was received. The content of this article is the sole responsibility of the authors, and not that of the journal or its publishers.

Please note that supplementary movies are not available online at this stage. Once a paper is published in its edited and formatted form, it will be accompanied online by any supplementary movies.

To read the full content of this article, please download the PDF. Download full article (PDF)

Sign in to read and download the full article

Forgot your password?
No account yet? Sign up for free!
Create my pcr account

Join us for free and access thousands of articles from EuroIntervention, as well as presentations, videos, cases from PCRonline.com

Aims: This study sought to compare thromboresistance and albumin binding capacity of different durable polymer DESs using dedicated preclinical and in vitro models.

Methods and Results: In an ex vivo swine arterio-venous shunt model, fluoropolymer everolimus-eluting stent (FP-EES) (n=14) was compared with two durable polymer DES (BioLinx polymer coated zotarolimus-eluting stent (BL-ZES)(n=9) and a CarboSil® elastomer polymer coated ridaforolimus-eluting stent (EP-RES)(n=6)), and bare metal stents (BMS)(n=10). Stents underwent immunostaining using a cocktail of anti-platelet antibodies and a marker for inflammation and then were evaluated by confocal microscopy (CM). Albumin retention was assessed by using a flow loop model with labeled human serum albumin [FP-EES(n=8), BL-ZES(n=4), EP-RES(n=4), and BMS(n=7)] and scanned by CM. The area of platelet adherence (normalized to total stent surface area) was lower in order of FP-EES (9.8%), BL-ZES (32.7%), EP-RES (87.6%) and BMS (202.0%) and inflammatory cell densities was least for FP-EES<BL-ZES<EP-RES<BMS. Although nearly full coverage by albumin binding was shown for all durable polymer DES, FP-EES showed significantly greater intensity of albumin as compared to BL-ZES, EP-RES and BMS (FP-EES;79.0%, BL-ZES;13.2%, EP-RES;6.1%, BMS;1.5%).

Conclusions: These results suggest that thromboresistance, and albumin retention vary by polymer type and that these differences might result in different suitability for short-term dual antiplatelet therapy.

Read next article

Thermodilution-Derived Temperature Recovery Time, a Novel Predictor of Microvascular Reperfusion and Prognosis After Myocardial Infarction