Coronary interventions

Comparative effectiveness analysis of percutaneous coronary intervention versus coronary artery bypass grafting in patients with chronic kidney disease and unprotected left main coronary artery disease

EuroIntervention 2020;16:27-35. DOI: 10.4244/EIJ-D-18-01206

Dae-Won Kim
Dae-Won Kim1, MD, PhD; Sang Yong Om2, MD; Mahn-Won Park1, MD, PhD; Ha Wook Park1, MD; Pil Hyung Lee2, MD, PhD; Do-Yoon Kang2, MD; Jung-Min Ahn2, MD, PhD; Cheol Whan Lee2, MD, PhD; Seong-Wook Park2, MD, PhD; Seung-Jung Park2, MD, PhD; Sung-Ho Her1, MD, PhD; Duk-Woo Park2, MD, PhD
1. Division of Cardiology, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 2. Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

Aims: Outcomes according to the status of renal insufficiency have not been fully evaluated in left main coronary artery disease (LMCAD). In the present study therefore, we sought to evaluate clinical outcomes in patients with significant LMCAD stratified by the degree of renal insufficiency and the relative clinical outcomes after PCI and CABG stratified by the differential levels of renal function using data from the large multinational “all-comers” Interventional Research Incorporation Society-Left MAIN Revascularization (IRIS-MAIN) registry.

Methods and results: Among 4,894 patients with LMCAD, renal insufficiency was graded according to the estimated glomerular filtration rate (eGFR). The primary outcome was major adverse cardiac and cerebrovascular events (MACCE), defined as death, myocardial infarction, stroke, or any revascularisation. The patients were stratified into three groups according to eGFR: 3,824 (78%) in group 1 (eGFR ≥60 ml·min–1·1.73 m2), 838 (17%) in group 2 (eGFR ≥30 and <60), and 232 (5%) in group 3 (eGFR <30). At two years, after adjustment, compared with group 1, the risk of MACCE was significantly higher in group 2 (hazard ratio [HR] 1.46, 95% confidence interval [CI]: 1.18-1.79) and in group 3 (HR 3.39, 95% CI: 2.61-4.40). The p interaction for MACCE across groups was 0.20. The adjusted risk of MACCE was similar between percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in groups 1 and 2. However, PCI was associated with a significantly higher risk of MACCE compared to CABG (HR 1.88, 95% CI: 1.08-3.25) in group 3.

Conclusions: The degree of renal insufficiency was proportionately associated with unfavourable outcomes in patients with LMCAD. In group 3, PCI was associated with a higher risk of MACCE compared with CABG. Also, the effect of PCI versus CABG on MACCE was consistent, with PCI being associated with less bleeding and CABG being associated with less repeat revascularisation.

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deathleft mainrenal insufficiency
Coronary interventionsLeft main and multivessel disease
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