The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Editorial

Biodegradable or biocompatible polymer drug-eluting stent: a Gordian knot

EuroIntervention 2015;11:250-252. DOI: 10.4244/EIJV11I3A48

1. Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; 2. Fu Wai Hospital, National Center for Cardiovascular Diseases, Beijing, China


Percutaneous coronary intervention with drug-eluting stents (DES) has substantially improved clinical outcomes in patients with coronary artery disease, when compared with bare metal stents. However, permanent polymers of first-generation DES were linked with local inflammation, hypersensitivity reactions, and neoatherosclerosis, leading to an increased risk of very late stent thrombosis and DES failure at long-term follow-up. Recently, studies and meta-analyses have shown superiority of the new-generation DES with biodegradable or biocompatible polymer to previous-generation DES in terms of improved clinical outcomes1,2. However, whether the long-term clinical performance of these two types of DES after implantation is comparable remains debatable.

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