The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)
Automatic Characterisation of Human Atherosclerotic Plaque Composition from Intravascular Optical Coherence Tomography Using Artificial Intelligence
Miao Chu1; Haibo Jia2; Juan Luis Gutiérrez-Chico3; Akiko Maehara4; Ziad A. Ali4; Xiaoling Zeng5; Luping He2; Chen Zhao2; Mitsuaki Matsumura6; Peng Wu1; Ming Zeng2; Takashi Kubo7; Bo Xu8; Lianglong Chen5; Bo Yu2; Gary S. Mintz6; William Wijns9; Niels R. Holm10; Shengxian Tu11;
1. School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China 2. Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, Harbin, China 3. Cardiology Department, Campo de Gibraltar Health Trust, Algeciras, Spain 4. Center for Interventional Vascular Therapy, Division of Cardiology, Presbyterian Hospital and Columbia University, New York, New York; Cardiovascular Research Foundation, New York, New York 5. Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China 6. Cardiovascular Research Foundation, New York, New York 7. Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan 8. Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China 9. The Lambe Institute for Translational Medicine and Curam, National University of Ireland Galway, Ireland 10. Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark 11. School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China; Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China, China
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Background Intravascular optical coherence tomography (IVOCT) enables detailed plaque characterisation in-vivo, but visual assessment is time-consuming and subjective.
Aims This study aims to develop and validate an automatic framework for IVOCT plaque characterisation using artificial intelligence (AI).
Methods IVOCT pullbacks from 5 international centres were analysed in a corelab, annotating basic plaque components, inflammatory markers and other structures. A deep convolutional network with encoding-decoding architecture and pseudo-3D input was developed and trained using hybrid loss. The proposed network was integrated into commercial software to be externally validated on additional IVOCT pullbacks from three international corelabs, taking the consensus among corelabs as reference.
Results Annotated images from 509 pullbacks (391 patients) were divided into 10,517 and 1,156 cross-sections for the training and testing datasets, respectively. Dice coefficient of the model was 0.906 for fibrous plaque, 0.848 for calcium and 0.772 for lipid in the testing dataset. Excellent agreement in plaque burden quantification was observed between the model and manual measurements (R2=0.98). In the external validation, the software correctly identified 518 out of 598 plaque regions from 300 IVOCT cross-sections, with a diagnostic accuracy of 97.6%[95%CI:93.4%-99.3%] in fibrous plaque, 90.5%[95%CI:85.2%-94.1%] in lipid and 88.5%[95%CI:82.4%-92.7%] in calcium. The median time required for analysis was 21.4 (18.6-25.0) seconds per pullback.
Conclusions A novel AI framework for automatic plaque characterisation in IVOCT was developed, providing excellent diagnostic accuracy in both internal and external validation. This model might reduce subjectivity in image interpretation and facilitate IVOCT quantification of plaque composition, with potential applications in research and IVOCT-guided PCI.