The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)
A systematic review and meta-analysis of surgical outcomes following mitral valve surgery in octogenarians: implications for transcatheter mitral valve interventions
EuroIntervention 2014;9:1225-1234 published online ahead of print September 2013.
Ali Andalib1, MD, MSc; Samuel Mamane1, MD; Ian Schiller2, MSc; Andrea Zakem1, BSc; Darren Mylotte1, MD; Giuseppe Martucci1, MD; Pascal Lauzier1, PhD; Waleed Alharbi1, MD; Renzo Cecere3, MD; Magdalena Dorfmeister4, MD; Ruediger Lange4, MD, PhD; James Brophy2, MD, PhD; Nicolo Piazza1,4* MD, PhD
1. Department of Medicine, Division of Cardiology, Interventional Cardiology, McGill University Health Centre, Montreal, Quebec, Canada; 2. Department of Epidemiology and Biostatistics, McGill University Health Centre, Montreal, Quebec, Canada; 3. Departm
Aims: To evaluate the outcomes of mitral valve surgery in octogenarians with severe symptomatic mitral regurgitation (MR).
Methods and results: We performed a systematic review and meta-analysis of data on octogenarians who underwent mitral valve replacement (MVR) or mitral valve repair (MVRpr). Our search yielded 16 retrospective studies. Using Bayesian hierarchical models, we estimated the pooled proportion of 30-day mortality, postoperative stroke, and long-term survival. The pooled proportion of 30-day postoperative mortality was 13% following MVR (10 studies, 3,105 patients, 95% credible interval [CI] 9-18%), and 7% following MVRpr (six studies, 2,642 patients, 95% CI: 3-12%). Furthermore, pooled proportions of postoperative stroke were 4% (six studies, 2,945 ...