Yoshinobu Onuma1, MD, PhD; Patrick W. Serruys1,2, MD, PhD
1. National University of Ireland, Galway, Ireland; 2. Imperial College London, London, United Kingdom
Concept and design of a bioresorbable scaffold, which “does its job and disappears”
A fully bioresorbable scaffold (BRS) should be viewed as a transient coronary implantation device which prevents acute recoil and constrictive remodelling for a limited duration of time, elutes an antiproliferative drug to avoid excessive neointimal hyperplasia and then disappears by biodegradation (“does its job and disappears”)1. Since the peak of chronic vascular constriction and neointima hyperplasia occurs approximately three to six months after balloon angioplasty and/or bare metal stenting2,3,4, a BRS providing mechanical support for three to six months with ...