Peripheral interventions

MicroNET-covered stents for embolic prevention in patients undergoing carotid revascularisation: twelve-month outcomes from the PARADIGM study

EuroIntervention 2020;16:e950-e952. DOI: 10.4244/EIJ-D-19-01014

Adam Mazurek
Adam Mazurek1, MD, PhD; Anna Borratynska2, MD, PhD; Krzysztof P. Malinowski3,4; Mateusz Brozda1, MSc; Urszula Gancarczyk1, MD; Natalia Dluzniewska1, MD; Lukasz Czyz1, MD; Martyna Duplicka1, MD; Ewa Sobieraj1, MD; Mariusz Trystula5, MD, PhD; Tomasz Drazkiewicz5, MD, PhD; Piotr Podolec1, MD, PhD; Piotr Musialek1, MD, DPhil
1. Jagiellonian University, Department of Cardiac & Vascular Diseases, John Paul II Hospital, Krakow, Poland; 2. Neurology Outpatient Department, John Paul II Hospital, Krakow, Poland; 3. KCRI Data Management Division, Krakow, Poland; 4. Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland; 5. Department of Vascular Surgery, John Paul II Hospital, Krakow, Poland


Large clinical series of carotid artery stenting (CAS) using conventional carotid stents have shown that 40-80% of adverse neurologic events within the first 30 days occur post-procedurally rather than intraprocedurally, and often several days after the procedure1. Indeed, first-generation carotid stent use is associated with post-procedural cerebral embolism2 that largely results from intraluminal plaque prolapse through the struts3, a phenomenon which is not eliminated by the classic closed-cell design4.

Sequential cerebral imaging with diffusion-weighted magnetic resonance (including routine imaging at baseline, 24-48 hours and 30 days5) demonstrated that the MicroNET-covered embolic prevention stent CGuard™ (InspireMD, Tel Aviv, ...

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