Interventions for valvular disease and heart failure

Quantitative aortography for assessing aortic regurgitation after transcatheter aortic valve implantation: results of the multicentre ASSESS-REGURGE Registry

EuroIntervention 2019;15:420-426. DOI: 10.4244/EIJ-D-19-00362

Rodrigo Modolo
Rodrigo Modolo1,2, MD; Chun-Chin Chang3, MD; Hiroki Tateishi4, MD; Yosuke Miyazaki3,4, MD, PhD; Michele Pighi5, MD; Mohammad Abdelghani1,6, MD; Martin A. Roos3, BSc; Quinten Wolff3, BSc; Joanna J. Wykrzykowska1, MD, PhD; Robbert J. de Winter1, MD, PhD; Nicolo Piazza5, MD, PhD; Gert Richardt6, MD; Mohamed Abdel-Wahab6,7, MD; Osama I.I. Soliman3,8, MD, PhD; Yoshinobu Onuma3,8, MD, PhD; Nicolas M. Van Mieghem3, MD, PhD; Patrick W. Serruys9, MD, PhD
1. Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; 2. Department of Internal Medicine, Cardiology Division, University of Campinas (UNICAMP), Campinas, Brazil; 3. Department of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands; 4. Division of Cardiology - Department of Clinical Science and Medicine - Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan; 5. Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada; 6. The Heart Center, Segeberger Kliniken, Bad Segeberg, Germany; 7. Cardiology Department, Heart Center Leipzig at the University of Leipzig, Leipzig, Germany; 8. Cardialysis Clinical Trials Management and Core Laboratories, Rotterdam, the Netherlands; 9. Department of Cardiology, Imperial College London, London, United Kingdom

Aims: Quantitative aortography using videodensitometry is a valuable tool for quantifying paravalvular regurgitation after TAVI, especially in the minimalist approach – without general anaesthesia. However, retrospective assessment of aortograms showed moderate feasibility of assessment. We sought to determine the prospective feasibility of quantitative aortography after a protocol of acquisition.

Methods and results: This was a multicentre registry in Japan, Canada, the Netherlands and Germany including consecutive patients with Heart Team indication to undergo TAVI over a median period of 12 months. Operators performed final aortograms according to a pre-planned projection (either by CT or visually – Teng’s rule). An independent core laboratory (Cardialysis) analysed all images for feasibility and for regurgitation assessment. From the four centres included in the present analysis, a total of 354 patients underwent TAVI following the acquisition protocol and all the aortograms were analysed by the core lab. The analyses were feasible in 95.5% (95% confidence interval [CI]: 93.2% to 97.5%) of the cases. This rate of analysable assessment was significantly higher than the feasibility in previous validation studies, such as in the RESPOND population (95.5% vs. 57.5%, p<0.0001). No differences were observed among different planning strategies (CT 96.5% vs. Teng’s rule 93%, p=0.159; or Circle 98.5% vs. 3mensio 95.8% vs. Teng’s rule 93%, p=0.247).

Conclusions: ASSESS-REGURGE showed a high feasibility of assessment of regurgitation with quantitative aortography with protocoled acquisition. This may be of great importance for quantifying regurgitation in TAVI procedures (optimisation, guidance of post-dilatation), and in future clinical trials, in order to address sealing features of novel devices for TAVI objectively. Identifier: NCT03644784

Sign in to read and download the full article

Forgot your password?

No account yet?
Sign up for free!

Create my pcr account

Join us for free and access thousands of articles from EuroIntervention, as well as presentations, videos, cases from

aortic regurgitationparavalvular leaktavi
Read next article
New-generation mechanical circulatory support during high-risk PCI: a cross-sectional analysis

Latest news