Coronary interventions

Procedural microvascular activation in long lesions treated with bioresorbable vascular scaffolds or everolimus-eluting stents: the PROACTIVE trial

EuroIntervention 2020;16:e147-e154. DOI: 10.4244/EIJ-D-18-01138

Mariano Pellicano
Mariano Pellicano1,2, MD, PhD, MSc; Giuseppe Di Gioia1,2, MD; Giovanni Ciccarelli1, MD; Panagiotis Xaplanteris1, MD, PhD; Leen Delrue1, MD, PhD; Gabor G. Toth3, MD, PhD; Frederik Van Durme1, MD; Alex Heyse1, MD; Eric Wyffels1, MD; Marc Vanderheyden1, MD; Jozef Bartunek1, MD, PhD; Bernard De Bruyne1, MD, PhD; Emanuele Barbato1,2, MD, PhD
1. Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium; 2. Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy; 3. University Heart Center Graz, Medical University of Graz, Graz, Austria

Aims: Significant platelet activation after long stented coronary segments has been associated with periprocedural microvascular impairment and myonecrosis. In long lesions treated either with an everolimus-eluting bioresorbable vascular scaffold (BVS) or an everolimus-eluting stent (EES), we aimed to investigate (a) procedure-related microvascular impairment, and (b) the relationship of platelet activation with microvascular function and related myonecrosis.

Methods and results: Patients (n=66) undergoing elective percutaneous coronary intervention (PCI) in long lesions were randomised 1:1 to either BVS or EES. The primary endpoint was the difference between groups in changes of pressure-derived corrected index of microvascular resistance (cIMR) after PCI. Periprocedural myonecrosis was assessed by high-sensitivity cardiac troponin T (hs-cTnT), platelet reactivity by high-sensitivity adenosine diphosphate (hs-ADP)-induced platelet reactivity with the Multiplate Analyzer. Post-dilatation was more frequent in the BVS group, with consequent longer procedure time. A significant difference was observed between the two groups in the primary endpoint of ΔcIMR (p=0.04). hs-ADP was not different between the groups at different time points. hs-cTnT significantly increased after PCI, without difference between the groups.

Conclusions: In long lesions, BVS implantation is associated with significant acute reduction in IMR as compared with EES, with no significant interaction with platelet reactivity or periprocedural myonecrosis.

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drug-eluting stentbioresorbable scaffoldsfractional flow reservestable anginaother technique
Coronary interventionsStable CADStents and scaffolds
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