2. Department of Mechanical Engineering, University College London, United Kingdom.
3. Department of Interventional Cardiology, Thoraxcentre, Erasmus Medical Centre, Rotterdam, the Netherlands.
4. Arterius Ltd, Leeds, United Kingdom.
5. Imperial College London, London, United Kingdom.
6. AccelLAB Inc., Boisbriand, QC, Canada.
7. LKEB-Division of Image Processing, Department of Radiology, Leiden University Medical Centre, Leiden, the Netherlands.
8. Department of Mechanical Engineering, Melbourne School of Engineering, University of Melbourne, Parkville, Australia.
9. Institute of Cardiovascular Sciences, University College of London, London, United Kingdom.
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10. Department of Cardiology, Barts Heart Centre, London, United Kingdom.
11. School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom.
12. Department of Biomedical Engineering, Thoraxcentre, Erasmus Medical Centre, Rotterdam, the Netherlands.
As a public service to our readership, this article - peer reviewed by the Editors of EuroIntervention - has been published immediately upon acceptance as it was received. The content of this article is the sole responsibility of the authors, and not that of the journal or its publishers.
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Methods and results: In 15 nonatherosclerotic Yucatan mini pigs, ArterioSorb in 3.0/14 mm and Xience in 3.0/15 mm were implanted in 25 and 15 vessels, respectively. Acute performance was evaluated by using quantitative coronary angiography (QCA) and optical coherence tomography (OCT). Following three-dimensional reconstruction of coronary arteries, endothelial shear stress (ESS) was quantified using non-Newtonian steady-flow simulation. Acute recoil measured by QCA was comparable in the two arms. Post-procedural flow and scaffold/stent area by OCT did not differ between the two devices. ESS post-procedure was comparable between ArterioSorb and Xience (2.21±1.97 vs. 2.25±1.71 Pa, p=0.314).
Conclusions: Acute recoil, luminal dimensions and ESS in ArterioSorb oriented-PLLA scaffold with thin struts of 95 µm were comparable to Xience metallic DES.
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