The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Coronary interventions

Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb): acute-phase invasive imaging assessment and hemodynamic implication.

EuroIntervention 2020;16:e141-e146. DOI: 10.4244/EIJ-D-18-01190

1. Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, the Netherlands; 2. Department of Mechanical Engineering, University College London, London, United Kingdom; 3. Department of Interventional Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands; 4. First Department of Cardiology, Medical University of Warsaw, Warsaw, Poland; 5. Arterius Ltd, Leeds, United Kingdom; 6. Imperial College London, London, United Kingdom; 7. AccelLAB Inc., Boisbriand, QC, Canada; 8. LKEB-Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; 9. Department of Mechanical Engineering, Melbourne School of Engineering, University of Melbourne, Parkville, Australia; 10. Institute of Cardiovascular Sciences, University College London, London, United Kingdom; 11. Department of Cardiology, Barts Heart Centre, London, United Kingdom; 12. School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; 13. Department of Biomedical Engineering, Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands; 14. Department of Cardiology, National University of Ireland, Galway (NUIG), Galway, Ireland

Aims: The aim of this study was to assess the acute performance of the 95 µm ArterioSorb oriented poly L-lactic acid (PLLA) scaffold in comparison with the XIENCE metallic drug-eluting stent (DES) in porcine coronary arteries.

Methods and results: In 15 non-atherosclerotic Yucatan mini pigs, the ArterioSorb (3.0/14 mm) and XIENCE (3.0/15 mm) were implanted in 25 and 15 vessels, respectively. Acute performance was evaluated by using quantitative coronary angiography (QCA) and optical coherence tomography (OCT). Following three-dimensional reconstruction of the coronary arteries, endothelial shear stress (ESS) was quantified using non-Newtonian steady-flow simulation. Acute recoil measured by QCA was comparable in the two arms. Post-procedural flow and scaffold/stent area by OCT did not differ between the two devices. ESS post procedure was comparable between ArterioSorb and XIENCE (2.21±1.97 vs 2.25±1.71 Pa, p=0.314).

Conclusions: Acute recoil, luminal dimensions and ESS in the ArterioSorb oriented PLLA scaffold with thin struts of 95 µm were comparable to those in the XIENCE metallic DES.

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