The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Non-implant valve repair for calcific aortic stenosis: The Leaflex Study

DOI: 10.4244/EIJ-D-20-00458

1. Center for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London UK
2. Barts Heart Centre, St. Bartholomew's Hospital, London, UK, United Kingdom
3. University Hospital, SAOLTA Healthcare Group and the National University of Ireland, Galway
4. Sussex Cardiac Centre, Brighton and Sussex University Hospitals, UK
5. Kaplan Medical Center, Rehovot, Israel
6. Department of Cardiovascular Surgery and Transplantology, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland
7. Pi-Cardia, Rehovot Science Park, Israel
8. Gottsegen Hungarian Institute of Cardiology, Budapest, Hungary

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Senile calcific aortic stenosis (AS) is a multifactorial degenerative disease which results in calcification of the aortic valve leaflets. A bridging pattern of calcium involving both center and bases of the leaflets is typical and causes progressive restriction of valve opening, yielding the clinical syndrome of symptomatic AS. The Leaflex™ device is designed to score calcium deposits on the aortic surface of calcified aortic valve leaflets. The scoring lines aim to segment restrictive deposits and thereby increase mobility, reducing the severity of AS without implantation of a bioprosthetic valve. The device has undergone extensive bench testing in a reconstructed ...

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