The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)


Is clopidogrel as the P2Y12 inhibitor a wise choice for long-term monotherapy in patients undergoing stenting?

EuroIntervention 2021;17:e865-e866. DOI: 10.4244/EIJV17I11A144

1. Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Baltimore, MD, USA
International practice guidelines uniformly recommend dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor in patients undergoing drug-eluting stent (DES) implantation to reduce ischaemic events such as stent thrombosis. In high-risk coronary artery disease (CAD) patients, potent platelet P2Y12 inhibitors such as prasugrel or ticagrelor are preferred whereas in stable CAD patients clopidogrel is widely used1,2. A shorter duration of DAPT (1-3 months) followed by mono antiplatelet therapy has been suggested based on the significantly lower incidences of stent thrombosis with second-generation DES1,2. A recent meta-analysis suggested that de-escalation of DAPT after 1-3 months to monotherapy ...

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