The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

In vivo intravascular photoacoustic imaging of plaque lipid in coronary atherosclerosis

1. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
2. Technical University Eindhoven, Department of Biomedical Engineering, The Netherlands
3. Erasmus MC University Medical Center Rotterdam, Department of Experimental Medical Instrumentation, Rotterdam, The Netherlands
4. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
5. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
6. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
7. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
8. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
9. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
10. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands; Delft University of Technology, Department of Imaging Physics, Faculty of Applied Sciences, Delft, The Netherlands
11. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
12. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands, NETHERLANDS
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As a public service to our readership, this article - peer reviewed by the Editors of EuroIntervention - has been published immediately upon acceptance as it was received. The content of this article is the sole responsibility of the authors, and not that of the journal or its publishers. To read the full content of this article, please download the PDF.

Prospective identification of lipid-rich vulnerable plaque has remained an elusive goal. Intravascular photoacoustics, a hybrid optical and ultrasonic technology, was developed as a tool for lipid-rich plaque imaging. Here, we present the first in-vivo images of lipid-rich coronary atherosclerosis, acquired with this new technology in a large animal model, and relate them to independent catheter-based imaging and histology.

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