In vivo intravascular photoacoustic imaging of plaque lipid in coronary atherosclerosis

Sophinese Iskander-Rizk1; Min Wu2; Geert Springeling3; Heleen M.M. van Beusekom4; Frits Mastik5; Maaike te Lintel Hekkert6; Robert H.S.H Beurskens7; Ayla Hoogendoorn8; Eline M.J. Hartman9; Antonius F.W. van der Steen10; Jolanda J. Wentzel11; Gijs Van Soest12, PhD;

1. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
2. Technical University Eindhoven, Department of Biomedical Engineering, The Netherlands
3. Erasmus MC University Medical Center Rotterdam, Department of Experimental Medical Instrumentation, Rotterdam, The Netherlands
4. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
5. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
6. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
7. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
8. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
9. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
10. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands; Delft University of Technology, Department of Imaging Physics, Faculty of Applied Sciences, Delft, The Netherlands
11. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands
12. Erasmus MC University Medical Center Rotterdam, Department of Cardiology, Rotterdam, The Netherlands, NETHERLANDS

Disclaimer:

As a public service to our readership, this article - peer reviewed by the Editors of EuroIntervention - has been published immediately upon acceptance as it was received. The content of this article is the sole responsibility of the authors, and not that of the journal or its publishers. To read the full content of this article, please download the PDF.

Prospective identification of lipid-rich vulnerable plaque has remained an elusive goal. Intravascular photoacoustics, a hybrid optical and ultrasonic technology, was developed as a tool for lipid-rich plaque imaging. Here, we present the first in-vivo images of lipid-rich coronary atherosclerosis, acquired with this new technology in a large animal model, and relate them to independent catheter-based imaging and histology.

Forgot your password?

No account yet? Sign up for free!

Create my pcr account

Join us for free and access thousands of articles from EuroIntervention, as well as presentations, videos, cases from PCRonline.com

Share on Facebook Share on Twitter Share on Linkedin