First-in-human implantation of the Topaz transcatheter tricuspid valve replacement system

Introduction Severe tricuspid regurgitation (TR) is frequent and associated with poor outcomes1. Nevertheless, many patients are declined for surgery because of prohibitive surgical risks. In this setting, transcatheter tricuspid valve (TV) intervention may be a less invasive option. Transcatheter edge-to-edge repair (TEER) has been the most used approach so far2; however, transcatheter tricuspid valve replacement (TTVR) might be a more attractive strategy. Indeed, besides providing an alternative for patients whose anatomies are not suitable for TEER (due to large coaptation gaps or short/retracted septal leaflets), TTVR procedures are likely to be less challenging and more reproducible, as demonstrated in ...