The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)


Chemical sympathetic denervation: promising, but important distinctions between agents and methods

EuroIntervention 2017;13:e1131-e1132 published online e-edition October 2017. DOI: 10.4244/EIJ-D-16-01000R

1. CardioVascular Center Frankfurt, Frankfurt, Germany; 2. Preclinical Consultation, San Francisco, CA, USA; 3. Stepwise Medical LLC, Menlo Park, CA, USA; 4. University Hospital, Toulouse, France; 5. CVPath Institute Inc., Gaithersburg, MD, USA

We read with great interest the letter to the editor by Toutouzas et al and agree with the stated limitations regarding radiofrequency (RF)-mediated renal denervation as performed in studies using a single electrode RF catheter in the manner applied in SYMPLICITY-HTN 3, including the potential for vascular injury. Of equal importance, however, is the probable technique-dependent efficacy. It is possible that the limited tissue injury depth that can safely be achieved with RF ablation without protection of the intima in the main stem renal arteries together with the limited number of ablations contributed to the absence of a blood ...

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