Coronary interventions

BuMA Supreme biodegradable polymer sirolimus-eluting stent versus a durable polymer zotarolimus-eluting coronary stent: three-year clinical outcomes of the PIONEER trial

EuroIntervention 2020;16:e900-e903. DOI: 10.4244/EIJ-D-19-00566

Chun Chang
Chun Chin Chang1, MD; Norihiro Kogame2, MD; Taku Asano2, MD; Clemens von Birgelen3, MD, PhD; Manel Sabaté4, MD, PhD; Yoshinobu Onuma1,5, MD, PhD; Patrick W. Serruys6, MD, PhD
1. Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands; 2. Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; 3. Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Enschede, the Netherlands; 4. Department of Interventional Cardiology, Cardiovascular Institute, University Clinic Hospital, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; 5. Cardialysis B.V., Rotterdam, the Netherlands; 6. Department of Cardiology, National University of Ireland, Galway (NUIG), Galway, Ireland


The BuMA Supreme™ (SINOMED, Tianjin, China) is a sirolimus-eluting stent that has a biodegradable PLGA-polymer coating with an electro-grafting base layer on a thin-strut (80 µm) cobalt-chromium platform1. The PIONEER trial is a randomised study assessing the efficacy and safety of the BuMA Supreme compared with the Resolute™ stent (Medtronic, Minneapolis, MN, USA). The primary endpoint was the non-inferiority of the BuMA Supreme in terms of the nine-month angiographic in-stent late lumen loss (LLL). At nine months, the BuMA Supreme had a significantly higher in-stent LLL than the Resolute stent (0.29±0.33 vs 0.14±0.37 mm)1. Nevertheless, ...

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