The BuMA Supreme™ (SINOMED, Tianjin, China) is a sirolimus-eluting stent that has a biodegradable PLGA-polymer coating with an electro-grafting base layer on a thin-strut (80 µm) cobalt-chromium platform1. The PIONEER trial is a randomised study assessing the efficacy and safety of the BuMA Supreme compared with the Resolute™ stent (Medtronic, Minneapolis, MN, USA). The primary endpoint was the non-inferiority of the BuMA Supreme in terms of the nine-month angiographic in-stent late lumen loss (LLL). At nine months, the BuMA Supreme had a significantly higher in-stent LLL than the Resolute stent (0.29±0.33 vs 0.14±0.37 mm)1. Nevertheless, ...
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