The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

EDITORIAL

What determines low troponin concentrations in stable patients?

EuroIntervention 2016;12:296-297. DOI: 10.4244/EIJV12I3A47

Department of Cardiology and Cardiovascular Research School (COEUR), Erasmus MC, Rotterdam, The Netherlands


The “universal” definition of myocardial infarction (MI) is based on two key pillars: a clinical setting consistent with acute myocardial ischaemia, and evidence of cardiomyocyte necrosis, demonstrated by a rise and/or fall of cardiac troponins into the circulation with at least one value above the 99th percentile upper reference limit (URL99)1. The accuracy of this diagnosis in patients presenting with acute chest pain has been largely improved over the last decade through the development of so-called “high-sensitivity” troponin assays, which enable the detection and quantification of very low troponin concentrations2. However, the usefulness of the “universal” definition of ...

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