Coronary interventions

The SYNTAX score on its way out or … towards artificial intelligence: part II

EuroIntervention 2020;16:60-75. DOI: 10.4244/EIJ-D-19-00543B

Patrick Serruys
Patrick W. Serruys1, MD, PhD; Ply Chichareon2,3, MD; Rodrigo Modolo2,4, MD; David M. Leaman5, MD; Johan H.C. Reiber6, PhD; Håkan Emanuelsson7, MD; Carlo Di Mario8, MD, PhD; Nico H.J. Pijls9,10, MD, PhD; Marie-Angèle Morel11, BSc; Marco Valgimigli12, MD, PhD; Vasim Farooq13, MD, PhD; David van Klaveren14, PhD; Davide Capodanno15, MD, PhD; Daniele Andreini16,17, MD, PhD; Christos V. Bourantas18, MD, PhD; Justin Davies1, MD, PhD; Adrian P. Banning19, MD; Javier Escaned20, MD, PhD; Jan J. Piek2, MD, PhD; Mauro Echavarría-Pinto2, MD, PhD; Charles Anthony Taylor21, PhD; Brian Thomsen22, MSc; Carlos Collet2,23, MD; Giulio Pompilio16,17, MD, PhD; Antonio L. Bartorelli16,24, MD; Ben Glocker25, PhD; Ovidiu Dressler26, MD; Gregg W. Stone27, MD; Yoshinobu Onuma28, MD, PhD
1. NHLI, Imperial College London, London, United Kingdom; 2. Amsterdam UMC, University of Amsterdam, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands; 3. Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand; 4. Department of Internal Medicine, Cardiology Division, University of Campinas (UNICAMP), Campinas, Brazil; 5. Milton Hershey Medical Center, Penn State Heart and Vascular Institute, Hershey, PA, USA; 6. Department of Radiology, Division of Image Processing, Leiden University Medical Center, Leiden, the Netherlands; 7. Astra Charnwood Clinical R and D, Loughborough, United Kingdom; 8. Division of Structural Interventional Cardiology, Careggi University Hospital, Florence, Italy; 9. Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands; 10. Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands; 11. Cardialysis BV, Rotterdam, the Netherlands; 12. Department of Cardiology, Bern University Hospital, Bern, Switzerland; 13. University Hospital of Wales, Cardiff, United Kingdom; 14. Department of Public Health, Erasmus University Medical Center, Rotterdam, the Netherlands; 15. Division of Cardiology, Cardio-Thoracic-Vascular Department, Azienda Ospedaliero Universitaria “Policlinico-Vittorio Emanuele”, Catania, Italy; 16. Centro Cardiologico Monzino, IRCCS, Milan, Italy; 17. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy; 18. Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom; 19. Oxford Heart Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; 20. Department of Cardiology, Hospital Clinico San Carlos, Madrid, Spain; 21. HeartFlow, Redwood City, CA, USA; 22. GE Healthcare, Waukesha, WI, USA; 23. Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium; 24. Department of Biomedical and Clinical Sciences “Luigi Sacco”, University of Milan, Milan, Italy; 25. Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, United Kingdom; 26. Cardiovascular Research Foundation, New York, NY, USA; 27. The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York and the Cardiovascular Research Foundation, New York, NY, USA; 28. Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands


Following the CABRI1 and ARTS2 trials on multivessel disease, a challenging new trial was proposed to surgeons, namely the SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery) trial, sponsored by Boston Scientific as an IDE FDA trial on the use of the TAXUS™ stent (Boston Scientific, Marlborough, MA, USA) in three-vessel disease and left main. Actually, the left main component of the trial was a proposal made by Marie-Claude Morice and Antonio Colombo. A surgeon, Friedrich Mohr (...

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