Editorial

DOI: 10.4244/EIJ-E-24-00040

The patent foramen ovale does not spontaneously close in patients aged 60

David Hildick-Smith1, MD; Sandeep Arunothayaraj2, MD

Patent foramen ovale (PFO) closure for the prevention of recurrent stroke has travelled a long and winding road to acceptance. The first report of paradoxical embolism through a PFO was published in 1877, but it was not until the 1980s that PFOs were noted to be much more common in the setting of cryptogenic stroke1. Early randomised trials of PFO closure were disappointing – largely because the treatment was available outside clinical trials, and therefore, higher-risk patients were often offered PFO closure and only lower-risk individuals were randomised. More recent trials, however, with increased patient numbers and longer follow-up, have demonstrated the safety and efficacy of PFO closure for the prevention of recurrent stroke2.

PFO closure reduces the risk of stroke by preventing transit of venous thrombus. The clinical trials, aiming for clean data, restricted entrants to those under the age of 60. This strategy was vindicated when the trials were finally positive but has resulted in the disenfranchisement of patients over 60 with likely PFO-related stroke3. Funding bodies, possibly alarmed by the sheer prevalence of PFO, have...

Sign in to read
the full article

Forgot your password?
No account yet?
Sign up for free!

Create my pcr account

Join us for free and access thousands of articles from EuroIntervention, as well as presentations, videos, cases from PCRonline.com

Volume 20 Number 16
Aug 19, 2024
Volume 20 Number 16
View full issue


Key metrics

Suggested by Cory

10.4244/EIJV12SXA2 May 16, 2016
Patent foramen ovale: indications for closure and techniques
Taramasso M et al
free

10.4244/EIJY14M06_03 Oct 20, 2014
The tsunami of meta-analyses of patent foramen ovale closure for secondary prevention of cryptogenic stroke
Tzu Min Wang M and Kai Ming Wang T
free

CLINICAL RESEARCH

10.4244/EIJV10I12A257 Apr 20, 2015
Very long-term follow-up after percutaneous closure of patent foramen ovale
Eeckhout E et al
free

Viewpoint

10.4244/EIJ-D-21-00500 Oct 20, 2021
My stroke story
Noc M
free

10.4244/EIJV14I13A244 Jan 18, 2019
Patent foramen ovale: the known unknowns
Thaler D and Gans S
free
Trending articles
151.43

State-of-the-Art

10.4244/EIJ-D-22-00776 Apr 3, 2023
Computed tomographic angiography in coronary artery disease
Serruys PW et al
free
55.9

Clinical research

10.4244/EIJ-D-22-00621 Feb 20, 2023
Long-term changes in coronary physiology after aortic valve replacement
Sabbah M et al
free
54.9

Expert review

10.4244/EIJ-D-21-01010 Jun 24, 2022
Device-related thrombus following left atrial appendage occlusion
Simard T et al
free
43.75

Clinical Research

10.4244/EIJ-D-21-01091 Aug 5, 2022
Lifetime management of patients with symptomatic severe aortic stenosis: a computed tomography simulation study
Medranda G et al
free
39.95

Clinical research

10.4244/EIJ-D-22-00558 Feb 6, 2023
Permanent pacemaker implantation and left bundle branch block with self-expanding valves – a SCOPE 2 subanalysis
Pellegrini C et al
free
X

The Official Journal of EuroPCR and the European Association of Percutaneous Cardiovascular Interventions (EAPCI)

EuroPCR EAPCI
PCR ESC
Impact factor: 7.6
2023 Journal Citation Reports®
Science Edition (Clarivate Analytics, 2024)
Online ISSN 1969-6213 - Print ISSN 1774-024X
© 2005-2024 Europa Group - All rights reserved