Long-term effectiveness and safety of transcatheter closure of patent foramen ovale compared with antithrombotic therapy alone: a meta-analysis of six randomised clinical trials and 3,560 patients with reconstructed time-to-event data

EuroIntervention 2018;14:857-867 published online June 2018. DOI: 10.4244/EIJ-D-18-00341

Daniele Giacoppo
Daniele Giacoppo1,2,3*, MD; Nicola Caronna3, MD; Antonio H. Frangieh1,2, MD, MPH; Jonathan Michel1,2, MBBS; Giuseppe Andò4, MD, PhD; Giuseppe Tarantini5, MD, PhD; Albert M. Kasel1,2, MD; Davide Capodanno6,7, MD, PhD; Robert A. Byrne1,8, MB, BCh, PhD
1. Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; 2. Munich Structural Heart Institute, Munich, Germany; 3. Azienda Ospedaliero-Universitaria “Policlinico Giaccone”, University of Palermo, Palermo, Italy; 4. Azienda Ospeda

Aims: Although three recent trials have shown a significant stroke risk reduction after tPFOc, the individual statistical power is limited and the impact on pooled evidence needs to be ex

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pfo closureprior strokeprior transient ischaemic attackstroke
Interventions for strokeIschaemic strokeOther stroke interventions
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