The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Pulmonary hemodynamic effects of interatrial shunt in heart failure with preserved ejection fraction in rats

EuroIntervention 2019; just accepted article published in May 2019. DOI: 10.4244/EIJ-D-18-01100

1. Denis Diderot University, Xavier Bichat Hospital, Assistance Publique - Hopitaux de Paris, Paris, France, FRANCE; 2. Denis Diderot University, Xavier Bichat Hospital, Assistance Publique – Hôpitaux de Paris, Paris, France; 3. Denis Diderot University, Xavier Bichat Hospital, Assistance Publique – Hôpitaux de Paris, Paris, France; 4. Denis Diderot University, Xavier Bichat Hospital, Assistance Publique – Hôpitaux de Paris, Paris, France; 5. Denis Diderot University, Xavier Bichat Hospital, Assistance Publique – Hôpitaux de Paris, Paris, France; 6. Denis Diderot University, Xavier Bichat Hospital, Assistance Publique – Hôpitaux de Paris, Paris, France
Disclaimer:

As a public service to our readership, this article - peer reviewed by the Editors of EuroIntervention - has been published immediately upon acceptance as it was received. The content of this article is the sole responsibility of the authors, and not that of the journal or its publishers.

To read the full content of this article, please log in to download the PDF.

Aims: The aim of this study is to evaluate the effect of creation of a left-to-right interatrial shunt on pulmonary hemodynamics in rats with heart failure with preserved ejection fraction (HFPEF).

Methods and results: An interatrial communication (IAC) was created in 11 healthy rats (Lewis rats) and 11 rats which developed (HFPEF) (36-week-old spontaneously hypertensive rats (SHR)). Effects of the interatrial shunt were compared to 11 sham-operated Lewis and 11 sham-operated SHR. At 45 days post-shunt, strain effect was observed in diastolic function (E/A ratio, p<0.001; Isovolumetric relaxation time, p<0.001), left atrial volume (p=0.005) and pulmonary wall shear rate (WSR) (p=0.02) measured by echo-doppler. At animals’ sacrifice (60 days), a strain effect was also noted in elastin density (p=0.003) and eNOS protein expression (p= 0.001). Interatrial shunt creation resulted in (i) an increase in pulmonary WSR (p=0.04) and a decrease in left atrial volume (p<0.001); (ii) an increase in elastin density (p<0.005), and (iii) an increase in eNOS protein expression (p=0.03).

Conclusions: Creation of a left-to-right atrial shunt in rats with HFPEF was effective in improving pulmonary hemodynamics. Nevertheless, this study also provides preliminary evidences of the potential risk of right volume overload and pulmonary hypertension due to atrial shunting.

Sign in to read and download the full article

Forgot your password?
No account yet? Sign up for free!
Create my pcr account

Join us for free and access thousands of articles from EuroIntervention, as well as presentations, videos, cases from PCRonline.com

Read next article

Serial comparison of neointimal hyperplasia between the thin strut MiStent with microcrystalline sirolimus and the durable polymer coated everolimus-eluting Xience stent: 6- and 24-month results of DESSOLVE III OCT sub-study