The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)


Prevalence, predictors, and health status implications of periprocedural complications during coronary chronic total occlusion angioplasty

EuroIntervention 2018;14:e1199-e1206 published online May 2018 published online e-edition December 2018. DOI: 10.4244/EIJ-D-17-00976

1. The Christ Hospital Heart and Vascular Center and The Lindner Research Center, Cincinnati, OH, USA; 2. Monash Heart, Melbourne, Australia; 3. Division of Cardiology, Columbia University New York, NY, USA; 4. Division of Cardiology, Albert Einstein Medical Center, Philadelphia, PA, USA; 5. University of Missouri, Kansas City and Mid America Heart Institute, Kansas City, MO, USA; 6. Division of Cardiology, University of Washington, Seattle, WA, USA

Aims: Contemporary coronary chronic total occlusion (CTO) PCI has been associated with increased success rates. However, the rate of periprocedural complications for hybrid CTO PCI remains incompletely defined. We leveraged the OPEN CTO study in order to describe the prevalence, predictors, and health status outcomes of complications during contemporary CTO PCI.

Methods and results: Baseline demographics, procedural characteristics and rates of in-hospital complications were prospectively collected for 1,000 consecutive procedures at 12 expert US centres from 02/2014 to 07/2015. Multivariable logistic regression was used to evaluate the association of pre-specified anatomic and physiologic variables with complications. Patient-reported health status measures over the year following CTO PCI were also compared between those with and those without periprocedural complications. The overall complication rate was 9.7% (n=97/1,000). The most common adverse events were perforation (8.8%), periprocedural myocardial infarction (2.6%), arrhythmia requiring treatment (1.2%), cardiogenic shock (1.1%), and in-hospital death (0.9%). Independent predictors of complications during CTO PCI were: use of the retrograde approach (OR 1.98, 95% CI: 1.32-2.99), age (OR 1.30, 95% CI: 1.07-1.58 per 10-year increment), and J-CTO score (OR 1.20, 95% CI: 1.03-1.41 per one point increment). Mean health status scores over 12 months were worse for patients who experienced complications compared to those who did not, even after adjusting for baseline health status.

Conclusions: Complication rates for CTO PCI are more frequent than those reported for non-CTO PCI and were independently associated with retrograde approach, increasing age, and increasing lesion complexity. In addition, these periprocedural complications were also associated with worse long-term health status outcomes.

Sign in to read and download the full article

Forgot your password?
No account yet? Sign up for free!
Create my pcr account

Join us for free and access thousands of articles from EuroIntervention, as well as presentations, videos, cases from

Read next article
Randomised comparison of a biodegradable polymer ultra-thin sirolimus-eluting stent versus a durable polymer everolimus-eluting stent in patients with de novo native coronary artery lesions: the meriT-V trial