The Official Journal of EuroPCR and the European Association of Percutaneous Coronary Interventions (EAPCI)

Interventions for hypertension and stroke

Neuroprotection by selective endovascular brain cooling – the TwinFlo™ Catheter

EuroIntervention 2020;15:1291-1296. DOI: 10.4244/EIJ-D-19-00316

1. ThermopeutiX, Inc., San Diego, CA, USA; 2. Department of Endovascular and Cerebrovascular Neurosurgery, University of Rochester Medical Center, Rochester, NY, USA; 3. Departments of Clinical Neurological Sciences, Medical Imaging and Otolaryngology, Western University / London Health Sciences Centre, University Hospital, London, ON, Canada; 4. Department of Cardiology, Shaare Zedek Medical Center, Jerusalem, Israel

The neuroprotective effects of hypothermia have been demonstrated in experimental models and clinical trials. Experimental studies indicate that improved efficacy and broadened indications can be achieved with moderate to deep hypothermia. The TwinFlo catheter was designed to provide very rapid, deep and selective brain cooling with faster cooling rates, and temperatures much lower than those which can be achieved by any other hypothermia device and technique. This report describes the experimental in vivo studies and initial clinical experience with the TwinFlo catheter.

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