Long-term predictors of target vessel failure after intracoronary lithotripsy: 12-month results from the France LILI registry

Benjamin Honton¹, MD; Hakim Benamer², MD; Benoit Lattuca³, MD, PhD; Thibault Lhermusier⁴, MD; Nicolas Amabile²^,⁵, MD, PhD; Frederic Marco⁶, MD; Janusz Lipiecki⁷, MD; Ashok Tirouvanziam⁸, MD; Julien Jeanneteau⁹, MD; Eric Van Belle¹⁰, MD, PhD; Alexandre Canville¹¹, MD; Grégoire Rangé¹², MD; Matthieu Périer¹³, MD; Jacques Monsegu¹⁴, MD; Thomas Cuisset¹⁵, MD, PhD; Géraud Souteyrand¹⁶, MD, PhD; Gonzalo Quaino¹⁷, MD; Marine Quillot¹⁸, MD; Gael Bouchou¹⁹, MD; Fabrice Leroy²⁰, MD; Christophe Saint Etienne²¹, MD; Sebastien Levesque²², MD; Antoine Gommeaux²³, MD; Antoine Gerbay²⁴, MD; Benjamin Seguy²⁵, MD; Benjamin Fialon²⁶, MD; Julien Adjedj²⁷, MD; Louis-Marie Desroche²⁸, MD; Luc Maillard²⁹, MD, PhD; Nicolas Lhoest³⁰, MD; Olivier Darremont³¹, MD; Martine Gilard³², MD, PhD; Edouardo Aptecar³³, MD; Pascal Motreff¹⁶, MD, PhD; Vincent Bataille³⁴, PhD; Philippe Commeau³⁵, MD; Guillaume Cayla³, MD, PhD

1. Department of Interventional Cardiology, Clinique Pasteur, Toulouse, France; 2. Department of Interventional Cardiology, Institut Cardiovasculaire Paris Sud, Massy, France; 3. Department of Interventional Cardiology, Nimes University Hospital, University of Montpellier, Nimes, France; 4. Department of Cardiology, Rangueil Toulouse University Hospital, University Paul Sabatier, Toulouse, France; 5. Department of Cardiology, Institut Mutualiste Montsouris, Paris, France; 6. Department of Cardiology, Clinique Croix du Sud, Quint-Fonsegrives, France; 7. Department of Interventional Cardiology, Pôle Santé République, Clermont-Ferrand, France; 8. Cardiology Department, Hôpital Privé le Confluent, Nantes, France; 9. Cardiology Department, Clinique Saint Joseph, Trélazé, France; 10. Department of Interventional Cardiology for Coronary, Valves and Structural Heart Diseases, CHU Lille, Lille, France; 11. Department of Cardiology, Clinique Saint Hilaire, Rouen, France; 12. Department of Cardiology, Chartres Hospital, Chartres, France; 13. Department of Cardiology, Foch Hospital, Suresnes, France; 14. Department of Interventional Cardiology, Institut Cardio-Vasculaire Groupe Hospitalier Mutualiste de Grenoble, Grenoble, France; 15. Interventional Cardiology Unit and Cathlab, Department of Cardiology, University Hospital La Timone, Marseille, France; 16. Department of Interventional Cardiology, Gabriel Montpied University Hospital, Clermont-Ferrand, France; 17. Department of Interventional Cardiology, CHITS, Toulon, France; 18. Department of Interventional Cardiology, CH Henri Duffaut, Avignon, France; 19. Department of Interventional Cardiology, CHU Saint Etienne, Saint-Priest-en-Jarez, France; 20. Department of Interventional Cardiology, Hôpital privé La Louvière, Lille, France; 21. Department of Interventional Cardiology, CHU Trousseau, Tours, France; 22. Department of Interventional Cardiology, CHU la Miletrie, Poitiers, France; 23. Department of Cardiology, Hôpital privé de Bois Bernard, Bois-Bernard, France; 24. Department of Interventional Cardiology, Hôpital privé de la Loire, Saint-Etienne, France; 25. Medico-Surgical Department (Valvulopathies, Cardiac Surgery, Adult Interventional Cardiology), Hôpital Cardiologique de Haut-Lévèque, Bordeaux University Hospital, Bordeaux, France; 26. Department of Interventional Cardiology, GCS Centre de Cardiologie du Pays Basque, Bayonne, France; 27. Department of Cardiology, Institut Arnault Tzanck, Saint-Laurent-du-Var, France; 28. Department of Cardiology, Hôpital Universitaire de La Réunion, Saint-Denis, Réunion, France and Centre d’Investigations Clinique - Épidémiologie Clinique INSERM 1410, Hôpital Universitaire de La Réunion, Réunion, France; 29. Department of Cardiology, GCS ES Axium Rambot, Aix-en-Provence, France; 30. Division of Cardiovascular Medicine, Clinique Rhéna, Strasbourg, France; 31. Interventional Cardiology Department, Clinique Saint-Augustin, Bordeaux, France; 32. Department of Cardiology, Brest University Hospital, Brest, France; 33. Department of Cardiology, Clinique les Fontaines, Melun, France; 34. Department of Cardiology, Rangueil Toulouse University Hospital, University Paul Sabatier, Toulouse, France and Association pour la Diffusion de la Médecine de Prévention (ADIMEP), Toulouse, France; 35. Department of Interventional Cardiology, Polyclinique Les Fleurs, Groupe ELSAN, Ollioules, France

Coronary artery calcification is a frequent challenge in percutaneous coronary intervention (PCI), often associated with suboptimal procedural outcomes due to difficulties in lesion crossing, stent expansion, and a poor long-term clinical prognosis1. Intravascular lithotripsy (IVL) offers a promising solution using acoustic waves to modify calcified lesions and increase vessel compliance before stenting. However, despite the growing adoption of IVL, particularly in patients with severe calcifications, real-world long-term data remain scarce2. The France LILI registry was established to assess the long-term safety and efficacy of IVL in a large cohort of unselected patients treated in routine clinical practice.

France LILI (ClinicalTrials.gov: NCT05113407) is a prospective, multicentre, national registry that included 500 patients from 34 centres across France, all of whom underwent PCI with adjunctive IVL using the Shockwave C2 coronary lithotripsy system (Shockwave Medical). The primary endpoint was target vessel failure (TVF) − a composite of cardiac death, all myocardial infarction (MI), and ischaemia-driven target vessel revascularisation (ID-TVR) − assessed at 12 months. Secondary endpoints included procedural success, device success, and identification of factors associated with TVF. All clinical events...

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Volume 21 Number 15

Aug 4, 2025