Letter to the editor

Letter: Caffeine and fractional flow reserve overestimation: a word of caution

EuroIntervention 2022;18:524. DOI: 10.4244/EIJ-D-21-01009L

Camilla Siig
Camilla Siig1, BSc; Mahmood Ahmad2, MBBS
1. University College London, London, United Kingdom; 2. Tahir Heart Institute, Chiniot, Punjab, Pakistan
We write in response to Tanaka et al with interest regarding their recent paper: “Linear concentration-response relationship of serum caffeine with adenosine-induced fractional flow reserve overestimation: a comparison with papaverine”1. This paper concludes that serum caffeine overestimates adenosine-induced fractional flow reserve (FFRADN), highlighting the need for standardised control of caffeine prior to FFR measurement. The consensus states that standardisation criteria are vitally important for fair clinical practice, though we caution against drawing early conclusions in defining these criteria made for the general population.

Kasumi et al outline their reference standards in Japanese patients: intravenous adenosine triphosphate infusion ...

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