INTERVENTIONAL FLASHLIGHT

DOI: 10.4244/EIJ-D-17-00871

Left atrial appendage closure: size does matter!

Guy Achkouty1, MD; Adela Rohnean2, MD; Christophe Caussin1, MD; Nicolas Amabile1*, MD, PhD

An 86-year-old woman was referred to our institution for percutaneous left atrial appendage (LAA) occlusion. She was contraindicated for oral anticoagulation after a severe haemorrhagic shock related to diverticular disease. Her CHA2DS2-VASc and HAS-BLED scores were 6 and 4, respectively.

Preprocedural cardiac computed tomography (CT) scan confirmed the absence of thrombus in the LAA, the dimensions of which were measured to 22 mm in the neck (Panel A). An intermediate atherosclerotic plaque in the proximal circumflex artery was also noticed (Panel B). The procedure was performed under general anaesthesia and transoesophageal echocardiography (TEE) guidance. The LAA landing zone and ostium diameters were measured at 20 and 22 mm, respectively, by TEE (Panel C), leading to the implantation of a 25 mm AMPLATZER™ Amulet™ occluder (St. Jude Medical, St. Paul, MN, USA). After the device deployment, angiographic and echocardiographic control showed correct disc and lobe alignment and a severe lobe compression (Panel D). A new ST elevation in the inferolateral leads was identified on ECG monitoring. Therefore, the device was retrieved into the shaft. Emergent coronary angiography showed a severe stenosis of the proximal circumflex artery just beside the LAA (Panel E). ST segment resolution was observed only a few minutes after device retrieval and intracoronary nitrate injection. A smaller 22 mm AMPLATZER™ Amulet™ device was then implanted (Moving image 1) before treating the coronary lesion.

An optical coherence tomography (OCT) analysis of the circumflex artery showed an acute destabilisation of the initial circumflex lesion, related to extrinsic compression and putative plaque haemorrhage (Panel F1, Panel F2, Moving image 2). A 2.25×24 mm everolimus-eluting stent (SYNERGY™ II; Boston Scientific, Marlborough, MA, USA) was then implanted with the help of specific bifurcation techniques (Panel G). The patient was discharged on dual antiplatelet therapy (aspirin and clopidogrel) for three months and the subsequent evolution was uneventful.

LAA occlusion procedures using the AMPLATZER™ Amulet™ device lead to low numbers of major adverse events. Hence, the most recent data report limited incidence of death (0.2%), major bleeding (2.4%), tamponade (1.2%), stroke (0.2%), major vascular complications (0.9%) or device embolisation (0.1%) after implantation1. To the best of our knowledge, this is the first report of a circumflex mechanical compression by LAA occluder device leading to atherosclerotic plaque destabilisation documented with OCT.

This case illustrates the issues in adequate device size choice, despite multimodal imaging analysis. In our case, the most plausible mechanism leading to destabilisation appears to be arterial extrinsic compression by the device’s lobe that induced plaque haemorrhage. Whether this complication could have been favoured by per-procedural anticoagulation remains unknown. Unfortunately, there is no recommendation regarding a systematic evaluation of the circumflex artery lumen and its intimate relation with the LAA before the procedure. This case advocates the cautious analysis of the pre-intervention cardiac CT scan.

Conflict of interest statement

N. Amabile and C. Caussin have received consulting fees from Abbott/St. Jude Medical. The other authors have no conflicts of interest to declare.

Supplementary data

Moving image 1. 22 mm AMPLATZER Amulet device implantation.

Moving image 2. Pre-PCI circumflex artery OCT analysis.

Supplementary data

To read the full content of this article, please download the PDF.

Moving image 1. 22 mm AMPLATZER Amulet device implantation.

Moving image 2. Pre-PCI circumflex artery OCT analysis.

Volume 13 Number 13
Jan 19, 2018
Volume 13 Number 13
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